The story of mRNA began is a tale of personal perseverance, eureka moments in the lab, soaring expectations — and an unprecedented flow of cash in biotech.
www.statnews.com
But behind the scenes the company’s scientists were running into a familiar problem. In animal studies, the ideal dose of their leading mRNA therapy was triggering dangerous immune reactions — the kind for which Karikó had improvised a major workaround under some conditions — but a lower dose had proved too weak to show any benefits.
Moderna had to pivot.
If repeated doses of mRNA were too toxic to test in human beings, the company would have to rely on something that takes only one or two injections to show an effect. Gradually, biotech’s self-proclaimed disruptor became a vaccines company......
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