Coronavirus

El Correcto

god is dead
*can't* hijack the nuclei
I read about it for like 5 minutes yesterday.
Apparently they repurposed ivermectin to help fight malaria in Africa because it kills the mosquitoes when they bite people who have it in their blood. It stops the vector for transmission, but doesn’t have any anti-viral qualities.

Is that right?
 

Fred's Myth

Nonhyphenated American
I read about it for like 5 minutes yesterday.
Apparently they repurposed ivermectin to help fight malaria in Africa because it kills the mosquitoes when they bite people who have it in their blood. It stops the vector for transmission, but doesn’t have any anti-viral qualities.

Is that right?
 

DriveInDriveOut

Inordinately Right
It works as an antiviral because it prevents viruses from invading the cell nuclei.
Apparently they repurposed ivermectin to help fight malaria in Africa because it kills the mosquitoes when they bite people who have it in their blood. It stops the vector for transmission, but doesn’t have any anti-viral qualities.

Is that right?
Tldr relevant section:
In light of the potential of ivermectin to prevent replication in a broad spectrum of viruses, the inhibition of importin α/β1-mediated nuclear import of viral proteins is suggested as the probable mechanism underlying its antiviral activity [6].
 

El Correcto

god is dead
“However, these results should be interpreted with caution. Firstly, it is important to note that the drug was only tested in vitro using a single line of monkey kidney cells engineered to express human signaling lymphocytic activation molecule (SLAM), also known as CDw150, which is a receptor for the measles virus [10]. Also, ivermectin has not been tested in any pulmonary cell lines, which are critical for SARS-CoV-2 in humans [11]. Furthermore, these authors did not show whether the reduction seen in RNA levels of SARS-CoV-2 following treatment with ivermectin would indeed lead to decreased infectious virus titers. Importantly, the drug concentration used in the study (5 μM) to block SARS-CoV-2 was 35-fold higher than the one approved by the FDA for treatment of parasitic diseases, which raises concerns about its efficacy in humans using the FDA approved dose in clinical trials [12].”

“Despite its promising antiviral and preliminary anti-inflammatory potential, the development of ivermectin formulations presents challenges, primarily due to its property of poor water solubility. Consequently, ivermectin's oral bioavailability remains low [28]. In addition, its pharmacokinetic profile may be affected by specific formulations, and minor differences in formulation design can modify plasma kinetics, biodistribution, and, consequentially, efficacy. For instance, ivermectin does not achieve adequate concentration levels in the human bloodstream necessary for treatment efficacy against ZIKV [29]. Therefore, novel delivery strategies are needed to optimize ivermectin bioavailability.”

“We hypothesize that micro- and nanotechnology-based systems for the pulmonary delivery of ivermectin may offer opportunities for accelerating the clinical re-purposing of this “enigmatic drug” in the context of SARS-CoV-2 infection, as recent advances in pharmaceutical technology and nanomaterials can be applied to the treatment of pulmonary infections [[24], [25], [26],[36], [37], [38], [39], [40]]. Despite the challenges faced in developing these drug delivery carriers, and uncertainty with regard to the efficacy of ivermectin, it indeed presents promising potential. In an optimistic scenario, new drug dosage forms may not only contribute to mitigate SARS-CoV-2 infection, but also be effective against other emerging viral diseases.”

It seems to me there are a lot of issues with just running out and grabbing a tube of ivermectin to start taking huge doses of. Ivermectin also has POTENTIAL though.
 

El Correcto

god is dead
I was use ivermectin as a right to try type scenario for dying people, but even then I wouldn’t have a lot of hope for the outcome.
Just from reading that article.
 

wilberforce15

Well-Known Member
I was use ivermectin as a right to try type scenario for dying people, but even then I wouldn’t have a lot of hope for the outcome.
Just from reading that article.
Like most treatments, use like that is why they allegedly fail so often. It's best used as a prophylactic. They give stupid doses to people on death's doorstep, and then throw the whole thing under the bus.
 

wilberforce15

Well-Known Member
Another example of intentional malfeasance by bribed docs:

Studies often include a methodology, and many/most of them have included directions to take ivermectin on an empty stomach.

That's sabotage.

Ivermectin is fat-soluble, and should be taken with a meal that has fat in it. Absorption and use rates differ dramatically, and they intentionally misused the medicine to make it less effective.
 

Analbumcover

ControlPkgs
Like most treatments, use like that is why they allegedly fail so often. It's best used as a prophylactic. They give stupid doses to people on death's doorstep, and then throw the whole thing under the bus.

Although that highlights part of the issue with COVID "treatment". Go home and get some bedrest and don't come back to the hospital until you're blue in the face and need to be put on a respirator. There doesn't seem to be any early/prophylactic treatment for covid other than "get vaccinated."

You have people on one side who believe the first thing they see and down 100ccs of Ivermectin while Big Pharma and social media are on the other side and outright shut down any conversation about alternative/preventative treatment under the label of "misinformation" because there's no profits to be had.

The cycle of skepticism, conspiracy theory and misinformation continues on and on and on.
 
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